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Catalytic Asymmetric Torgov Cyclization: A Concise Total Synthesis of (+)‐Estrone |
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| Authors: | Dr. Sébastien Prévost Dr. Nathalie Dupré Markus Leutzsch Dr. Qinggang Wang Dr. Vijay Wakchaure Prof. Dr. Benjamin List |
| Affiliation: | Max‐Planck‐Institut für Kohlenforschung, Kaiser‐Wilhelm‐Platz 1, 45470, Mülheim an der Ruhr (Germany) |
| Abstract: | An asymmetric Torgov cyclization, catalyzed by a novel, highly Brønsted acidic dinitro‐substituted disulfonimide, is described. The reaction delivers the Torgov diene and various analogues with excellent yields and enantioselectivity. This method was applied in a very short synthesis of (+)‐estrone. |
| Keywords: | disulfonimides estrone organocatalysis torgov cyclization total synthesis |