Total Synthesis of Gracilamine |
| |
| Authors: | Yingbo Shi Baochao Yang Shujun Cai Prof?Dr Shuanhu Gao |
| |
| Institution: | 1. Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, 3663N Zhongshan Road, Shanghai 200062 (China);2. Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032 (China) |
| |
| Abstract: | The total synthesis of gracilamine, a pentacyclic Amaryllidaceae alkaloid, was achieved from simple building blocks. The synthesis features a mild photo‐Nazarov reaction, intramolecular 1,4‐addition, and an intramolecular Mannich reaction. This approach not only confirms the C6 stereochemistry of natural gracilamine, and also provides a novel solution to prepare its derivatives and structurally related natural products. |
| |
| Keywords: | cross coupling cyclization natural products photochemistry total synthesis |
|
|
