Adaptive Amphiphilic Dendrimer‐Based Nanoassemblies as Robust and Versatile siRNA Delivery Systems |
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| Authors: | Xiaoxuan Liu Jiehua Zhou Tianzhu Yu Chao Chen Qiang Cheng Kheya Sengupta Yuanyu Huang Haitang Li Cheng Liu Yang Wang Paola Posocco Menghua Wang Qi Cui Suzanne Giorgio Maurizio Fermeglia Fanqi Qu Sabrina Pricl Yanhong Shi Zicai Liang Palma Rocchi John J. Rossi Ling Peng |
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| Affiliation: | 1. Aix‐Marseille Université, CNRS, Centre Interdisciplinaire de Nanoscience de Marseille, UMR 7325 (France);2. Centre de Recherche en Cancérologie de Marseille, INSERM, UMR1068 (France);3. Institut Paoli‐Calmettes, Marseille (France);4. Aix‐Marseille Université (France);5. CNRS, UMR7258, Marseille (France);6. Department of Molecular and Cellular Biology, Beckman Research Institute of City of Hope (USA);7. College of Chemistry and Molecular Sciences, Wuhan University (China);8. Institute of Molecular Medicine, Peking University (China);9. Molecular Simulation Engineering (MOSE), DEA, University of Trieste (Italy);10. Department of Neurosciences, Beckman Research Institute of City of Hope (USA);11. Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute of City of Hope (USA) |
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| Abstract: | siRNA delivery remains a major challenge in RNAi‐based therapy. Here, we report for the first time that an amphiphilic dendrimer is able to self‐assemble into adaptive supramolecular assemblies upon interaction with siRNA, and effectively delivers siRNAs to various cell lines, including human primary and stem cells, thereby outperforming the currently available nonviral vectors. In addition, this amphiphilic dendrimer is able to harness the advantageous features of both polymer and lipid vectors and hence promotes effective siRNA delivery. Our study demonstrates for the first time that dendrimer‐based adaptive supramolecular assemblies represent novel and versatile means for functional siRNA delivery, heralding a new age of dendrimer‐based self‐assembled drug delivery in biomedical applications. |
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| Keywords: | dendrimers gene silencing nanocarriers nonviral vectors self‐assembly |
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