Exceedingly Fast Copper(II)‐Promoted ortho CH Trifluoromethylation of Arenes using TMSCF3 |
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| Authors: | Ming Shang Shang‐Zheng Sun Dr. Hong‐Li Wang Dr. Brian N. Laforteza Prof. Dr. Hui‐Xiong Dai Prof. Dr. Jin‐Quan Yu |
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| Affiliation: | 1. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Shanghai 200032 (China);2. Department of Chemistry, Innovative Drug Research Center, Shanghai University, Shanghai 200444 (China);3. Department of Chemistry, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037 (USA) http://www.scripps.edu/chem/yu |
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| Abstract: | The direct ortho‐trifluoromethylation of arenes, including heteroarenes, with TMSCF3 has been accomplished by a copper(II)‐promoted C? H activation reaction which completes within 30 minutes. Mechanistic investigations are consistent with the involvement of C? H activation, rather than a simple electrophilic aromatic substitution (SEAr), as the key step. |
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| Keywords: | arenes C H activation copper fluorine reaction mechanisms |
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