|
|||||
|
|
Gold‐Catalyzed Diastereoselective Cycloisomerization of Alkylidene‐Cyclopropane‐Bearing 1,6‐Diynes |
|
| Authors: | Dr. Hongchao Zheng Laura L. Adduci Dr. Ryan J. Felix Prof. Dr. Michel R. Gagné |
| Affiliation: | Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599‐3290 (USA) |
| Abstract: | An unprecedented gold‐catalyzed diastereoselective cycloisomerization of 1,6‐diynes bearing an alkylidene cyclopropane moiety has been developed. This methodology enables rapid access to a variety of 1,2‐trimethylenenorbornanes, which are important building blocks in the preparations of abiotic and sesquiterpene core structures. |
| Keywords: | 1,6‐diynes cycloisomerization cyclopropylidenes gold catalysis synthetic methods |