Dearomative Indole [5+2] Cycloaddition Reactions: Stereoselective Synthesis of Highly Functionalized Cyclohepta[b]indoles |
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| Authors: | Guangjian Mei Hao Yuan Yueqing Gu Wei Chen Prof. Dr. Lung Wa Chung Prof. Dr. Chuang‐chuang Li |
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| Affiliation: | 1. Laboratory of Chemical Genomics, School of Chemical Biology andBiotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055 (China);2. Department of Chemistry, South University of Science andTechnology of China, Shenzhen 518055 (China) http://www.ligroup.com.cn |
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| Abstract: | The first dearomative indole [5+2] cycloaddition reaction with an oxidopyrylium ylide resulted in efficient and diastereoselective construction of some highly functionalized and synthetically challenging oxacyclohepta[b]indoles. The protocol proceeds under very mild reaction conditions, thus enabling high functional‐group tolerance and unique endo selectivity. |
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| Keywords: | cycloaddition diastereoselectivity heterocycles synthetic methods ylides |
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