Palladium‐Catalyzed Annulation of Diarylamines with Olefins through CH Activation: Direct Access to N‐Arylindoles |
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| Authors: | Dr Upendra Sharma Dr Rajesh Kancherla Togati Naveen Soumitra Agasti Prof Debabrata Maiti |
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| Institution: | 1. Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai‐400 076 (India);2. Current address: Natural Plant Product Division, CSIR‐IHBT, Palampur, H.P., India |
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| Abstract: | A palladium‐catalyzed dehydrogenative coupling between diarylamines and olefins has been discovered for the synthesis of substituted indoles. This intermolecular annulation approach incorporates readily available olefins for the first time and obviates the need of any additional directing group. An ortho palladation, olefin coordination, and β‐migratory insertion sequence has been proposed for the generation of olefinated intermediate, which is found to produce the expected indole moiety. |
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| Keywords: | C H activation cyclization indoles palladium reaction mechanisms |
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