Rhodium‐Catalyzed Cyclization of Diynes with Nitrones: A Formal [2+2+5] Approach to Bridged Eight‐Membered Heterocycles |
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| Authors: | Dr. Chunxiang Wang Dr. Dongping Wang Hao Yan Dr. Haolong Wang Dr. Bin Pan Dr. Xiaoyi Xin Dr. Xincheng Li Fan Wu Prof. Dr. Boshun Wan |
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| Affiliation: | Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023 (China) |
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| Abstract: | N‐aryl‐substituted nitrones were employed as five‐atom coupling partners in the rhodium‐catalyzed cyclization with diynes. In this reaction, the nitrone moiety served as a directing group for the catalytic C? H activation of the N‐aryl ring. This formal [2+2+5] approach allows rapid access to bridged eight‐membered heterocycles with broad substrate scope. The results of this study may provide new insight into the chemistry of nitrones and find applications in the synthesis of other heterocycles. |
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| Keywords: | alkenylation C H activation cyclization nitrones rhodium |
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