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Total Synthesis of Δ12‐Prostaglandin J3, a Highly Potent and Selective Antileukemic Agent |
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| Authors: | Prof?Dr K C Nicolaou Dr Philipp Heretsch Dr Abdelatif ElMarrouni Christopher R H Hale Dr Kiran K Pulukuri Dr Avinash K Kudva Dr Vivek Narayan Prof?Dr K Sandeep Prabhu |
| Institution: | 1. Department of Chemistry, BioScience Research Collaborative, Rice University, 6100 Main Street, Houston, TX 77005 (USA);2. Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802 (USA) |
| Abstract: | A catalytic asymmetric total synthesis of the potent and selective antileukemic Δ12‐prostaglandin J3 (Δ12‐PGJ3) is described. The convergent synthesis proceeded through intermediates 2 and 3 , formed enantioselectively from readily available starting materials and coupled through an aldol reaction followed by dehydration to afford stereoselectively the cyclopentenone alkylidene structural motif of the molecule. |
| Keywords: | asymmetric catalysis C H activation leukemia natural products total synthesis |