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Palladium‐Catalyzed Direct CH Functionalization of Benzoquinone |
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| Authors: | Sarah E. Walker Dr. James A. Jordan‐Hore Dr. David G. Johnson Prof. Dr. Stuart A. Macgregor Dr. Ai‐Lan Lee |
| Affiliation: | Institute of Chemical Sciences, Heriot‐Watt University, Edinburgh EH14 4AS (UK) |
| Abstract: | A direct Pd‐catalyzed C? H functionalization of benzoquinone (BQ) can be controlled to give either mono‐ or disubstituted BQ, including the installation of two different groups in a one‐pot procedure. BQ can now be directly functionalized with aryl, heteroaryl, cycloalkyl, and cycloalkene groups and, moreover, the reaction is conducted in environmentally benign water or acetone as solvents. |
| Keywords: | benzoquinone C H functionalization palladium synthetic methods water |