Iridium‐Catalyzed Regio‐ and Enantioselective Allylic Substitution of Silyl Dienolates Derived from Dioxinones |
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| Authors: | Ming Chen Prof John F Hartwig |
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| Institution: | Department of Chemistry, University of California, Berkeley, CA 94720 (USA) |
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| Abstract: | Reported herein is the iridium‐catalyzed regio‐ and enantioselective allylic substitution reactions of unstabilized silyl dienolates derived from dioxinones. Asymmetric allylic substitution of a variety of allylic trichloroethyl carbonates with these silyl dienolates gave γ‐allylated products selectively in 60–84 % yield and 90–98 % ee. |
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| Keywords: | alkylation allylic compounds asymmetric catalysis enantioselectivity iridium |
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