Gold‐Catalyzed Direct Hydrogenative Coupling of Nitroarenes To Synthesize Aromatic Azo Compounds |
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Authors: | Xiang Liu Hai‐Qian Li Sen Ye Dr Yong‐Mei Liu Prof?Dr He‐Yong He Prof?Dr Yong Cao |
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Institution: | Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai 200433 (P. R. China) |
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Abstract: | The azo linkage is a prominent chemical motif which has found numerous applications in materials science, pharmaceuticals, and agrochemicals. Described herein is a sustainable heterogeneous‐gold‐catalyzed synthesis of azo arenes. Available nitroarenes are deoxygenated and linked selectively by the formation of N?N bonds using molecular H2 without any external additives. As a result of a unique and remarkable synergy between the metal and support, a facile surface‐mediated condensation of nitroso and hydroxylamine intermediates is enabled, and the desired transformation proceeds in a highly selective manner under mild reaction conditions. The protocol tolerates a large variety of functional groups and offers a general and versatile method for the environmentally friendly synthesis of symmetric or asymmetric aromatic azo compounds. |
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Keywords: | arenes azo compounds gold reduction supported catalysts |
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