Regiocontrolled Gold‐Catalyzed [2+2+2] Cycloadditions of Ynamides with Two Discrete Nitriles to Construct 4‐Aminopyrimidine Cores |
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| Authors: | Somnath Narayan Karad Prof. Dr. Rai‐Shung Liu |
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| Affiliation: | Department of Chemistry, National Tsing Hua University, 101, Sec. 2, Kuang‐Fu Rd., Hsinchu, 30013 (Taiwan) http://chem‐en.web.nthu.edu.tw/files/13‐1117‐33454.php |
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| Abstract: | Reported herein is the novel gold‐catalyzed intermolecular [2+2+2] cycloaddition of ynamides with two discrete nitriles to form monomeric 4‐aminopyrimidines, which are pharmaceutically important structural motifs. The utility of this new cycloaddition is demonstrated by the excellent regioselectivity obtained using a variety of ynamides and nitriles. |
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| Keywords: | cycloadditions gold heterocycles homogeneous catalysis synthetic methods |
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