Photofunctional Nanomodulators for Bioexcitation |
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| Authors: | Dr Eijiro Miyako Dr Julie Russier Dr Matteo Mauro Dr Cristina Cebrian Prof Hiromu Yawo Dr Cécilia Ménard‐Moyon Dr James A Hutchison Dr Masako Yudasaka Prof Sumio Iijima Prof Luisa De Cola Dr Alberto Bianco |
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| Institution: | 1. Nanotube Research Center (NTRC), National Institute of Advanced Industrial Science and Technology (AIST), Central 5, 1‐1‐1 Higashi, Tsukuba 305‐8565 (Japan);2. CNRS, Institut de Biologie Moléculaire et Cellulaire, Laboratoire d'Immunopathologie et Chimie Thérapeutique, 15 Rue René Descartes, 67084 Strasbourg (France);3. Laboratoire de Chimie et des Biomatériaux Supramoléculaires, Institut de Science et d'Ingénierie Supramoléculaires (ISIS), Université de Strasbourg and CNRS, 8 allée Gaspard Monge, 67083 Strasbourg (France);4. Department of Developmental Biology and Neuroscience, Tohoku University, Graduate School of Life Sciences, Sendai 980‐8577 (Japan);5. Laboratoire des Nanostructures, Institut de Science et d'Ingénierie Supramoléculaires (ISIS), Université de Strasbourg and CNRS, 8 allée Gaspard Monge, 67083 Strasbourg (France) |
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| Abstract: | A single organism comprises diverse types of cells. To acquire a detailed understanding of the biological functions of each cell, comprehensive control and analysis of homeostatic processes at the single‐cell level are required. In this study, we develop a new type of light‐driven nanomodulator comprising dye‐functionalized carbon nanohorns (CNHs) that generate heat and reactive oxygen species under biologically transparent near‐infrared (NIR) laser irradiation. By exploiting the physicochemical properties of the nanohorns, cellular calcium ion flux and membrane currents were successfully controlled at the single‐cell level. In addition, the nanomodulator allows a remote bioexcitation of tissues during NIR laser exposure making this system a powerful tool for single‐cell analyses and innovative cell therapies. |
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| Keywords: | biological activity laser chemistry nanomaterials nanotechnology |
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