Diagnosis of Toxoplasmosis Using a Synthetic Glycosylphosphatidylinositol Glycan |
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Authors: | Dr Sebastian Götze Dr Nahid Azzouz Dr Yu‐Hsuan Tsai Prof?Dr Uwe Groß Anika Reinhardt Dr Chakkumkal Anish Prof?Dr Peter H Seeberger Dr Daniel Varón?Silva |
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Institution: | 1. Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14424 Potsdam (Germany);2. Institute of Chemistry and Biochemistry, Freie Universit?t Berlin, Arnimallee 22, 14195 Berlin (Germany);3. Nationales Konsiliarlabor Toxoplasma und Institut für Medizinische Mikrobiologie, Universit?tsmedizin G?ttingen (Germany) |
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Abstract: | Around 2 billion people worldwide are infected with the apicomplexan parasite Toxoplasma gondii which induces a variety of medical conditions. For example, primary infection during pregnancy can result in fetal death or mental retardation of the child. Diagnosis of acute infections in pregnant women is challenging but crucially important as the drugs used to treat T. gondii infections are potentially harmful to the unborn child. Better, faster, more reliable, and cheaper means of diagnosis by using defined antigens for accurate serological tests are highly desirable. Synthetic pathogen‐specific glycosylphosphatidylinositol (GPI) glycan antigens are diagnostic markers and have been used to distinguish between toxoplasmosis disease states using human sera. |
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Keywords: | biomarkers carbohydrate microarrays medicinal chemistry toxoplasmosis |
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