Iridium‐Catalyzed Enantioselective Allyl–Allylsilane Cross‐Coupling |
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| Authors: | James Y Hamilton Nicole Hauser Dr David Sarlah Prof?Dr Erick M Carreira |
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| Institution: | Laboratorium für Organische Chemie, Eidgen?ssische Technische Hochschule Zürich, HCI H335, Vladimir‐Prelog‐Weg 3, 8093 Zürich (Switzerland) http://www.carreira.ethz.ch |
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| Abstract: | An enantioselective allyl–allylsilane cross‐coupling involving racemic branched allylic alcohols and allylsilanes is reported. An iridium‐(P,olefin) phosphoramidite complex enables the transformation with high regio‐ and stereoselectivity under operationally simple conditions. The utility of the coupling is demonstrated in a concise catalytic, enantioselective synthesis of a pyrethroid insecticide protrifenbute. |
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| Keywords: | 1 5‐diene allylic substitution allylsilane enantioselectivity iridium |
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