One‐Pot Synthesis of Highly Substituted Polyheteroaromatic Compounds by Rhodium(III)‐Catalyzed Multiple CH Activation and Annulation |
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| Authors: | Jayachandran Jayakumar Dr Kanniyappan Parthasarathy Yi‐Hsiang Chen Tai‐Hua Lee Prof?Dr Shih‐Ching Chuang Prof?Dr Chien‐Hong Cheng |
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| Institution: | 1. Department of Chemistry, National Tsing Hua University, Hsinchu 30013 (Taiwan) http://mx.nthu.edu.tw/%7Echcheng;2. Department of Applied Chemistry, National Chiao Tung University, Hsinchu 30013 (Taiwan) |
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| Abstract: | A new method for the synthesis of highly substituted naphthyridine‐based polyheteroaromatic compounds in high yields proceeds through rhodium(III)‐catalyzed multiple C? H bond cleavage and C? C and C? N bond formation in a one‐pot process. Such highly substituted polyheteroaromatic compounds have attracted much attention because of their unique π‐conjugation, which make them suitable materials for organic semiconductors and luminescent materials. Furthermore, a possible mechanism, which involves multiple chelation‐assisted ortho C? H activation, alkyne insertion, and reductive elimination, is proposed for this transformation. |
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| Keywords: | alkynes annulation benzamidines C H activation rhodium |
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