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Studying Microstructure in Molecular Crystals With Nanoindentation: Intergrowth Polymorphism in Felodipine |
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| Authors: | Manish Kumar Mishra Prof Gautam R Desiraju Prof Upadrasta Ramamurty Prof Andrew D Bond |
| Institution: | 1. Solid State and Structural Chemistry Unit, Indian Institute of Science, Bangalore 560012 (India);2. Department of Materials Engineering, Indian Institute of Science, Bangalore 560012 (India);3. Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah 21589 (Saudi Arabia);4. Department of Pharmacy, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen ? (Denmark) |
| Abstract: | Intergrowth polymorphism refers to the existence of distinct structural domains within a single crystal of a compound. The phenomenon is exhibited by form II of the active pharmaceutical ingredient felodipine, and the associated microstructure is a significant feature of the compound’s structural identity. Employing the technique of nanoindentation on form II reveals a bimodal mechanical response on specific single‐crystal faces, demonstrating distinct properties for two polymorphic forms within the same crystal. |
| Keywords: | crystal engineering microstructure nanoindentation polymorphism X‐ray diffraction |