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Stereodivergent Total Synthesis of Δ9‐Tetrahydrocannabinols |
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| Authors: | Michael A Schafroth Giuseppe Zuccarello Simon Krautwald Dr David Sarlah Prof?Dr Erick M Carreira |
| Institution: | Laboratorium für Organische Chemie, Eidgen?ssische Technische Hochschule Zürich, HCI H335, Vladimir‐Prelog‐Weg 3, Zürich (Switzerland) http://www.carreira.ethz.ch |
| Abstract: | All four stereoisomers of Δ9‐tetrahydrocannabinol (Δ9‐THC) were synthesized in concise fashion using stereodivergent dual catalysis. Thus, following identical synthetic sequences and applying identical reaction conditions to the same set of starting materials, selective access to the four stereoisomers of THC was achieved in five steps. |
| Keywords: | dual catalysis stereodivergent synthesis tetrahydrocannabinol total synthesis |