Highly diastereo- and enantioselective NHC-catalyzed [3+2] annulation of enals and isatins |
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| Authors: | Sun Li-Hui Shen Li-Tao Ye Song |
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| Affiliation: | Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. |
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| Abstract: | The chiral N-heterocyclic carbene bearing a proximal hydroxy group derived from L-pyroglutamic acid was found to be an efficient catalyst for the [3+2] annulation of enals and isatins to give the corresponding spirocyclic oxindolo-γ-butyrolactones in good yield with good diastereo- and enantioselectivities. |
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