Antifungal activity of crown ethers |
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Authors: | Koji Yagi Veronica Garcia Ma. E. Rivas Javier Salas Andres Camargo Takeo Tabata |
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Affiliation: | (1) Departmento de Química, Universidad autónoma de Guadalajara, Lomas del Valle, Apdo Postal 1-440, 44, 100 Guadalajara, Jalisco, México;(2) Departmento de Química Agricola ICET, Universidad autónoma de Guadalajara, Lomas del Valle, Apdo Postal 1-440, 44, 100 Guadalajara, Jalisco, México |
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Abstract: | Some crown ethers were found to show significant antifungal activity against some wood-decay fungi, phytopathogenic fungi and eumycetes,Trichophytons for dermatomycosis. Their toxicity was evaluated by the paper disc method as well as by determining the values of ED50, i.e., the concentration which inhibits the mycelium growth by 50%. The fungi examined areTyromyces palustris, Picnoporous coccineus, Coriolous versicolor, Pyricularia filamentosa, Fusarium sp., Trichophyton rubrum, Trichophyton sp., etc. Among the 26 crown ethers tested, 3,5-di-t-butyl-benzo-15-crown-5 showed relatively high activity, the highest ED50 value of which being 8 M or 3 ppm. Other alkylbenzocrown ethers, dicyclohexyl crown ethers and Kryptofix 22DD also showed considerable activity. On the other hand, unsubstituted crown ethers, benzocrown ethers with a polar substituent, Kryptofix 222B and Kryptofix 221 were inactive. |
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