New Approach to the Synthesis of the Natural Product Aripuanin |
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| Authors: | Aline S Lazaro Pedro H Zana Ribeiro Mirela I Sairre |
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| Institution: | 1. Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeir?o Preto, Universidade de S?o Paulo, Ribeir?o Preto, Brazil;2. Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Santo André, Brazil |
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| Abstract: | AbstractAripuanin is a megastigmane that exists in the leaves of Ficus aripuanensis C.C. Berg (Moraceae). The present study describes a new approach to the total synthesis of this natural product starting from the readily available β-ionone. The proposed synthetic route provided racemic aripuanin in moderate yields (~31%). This route can be applied to the synthesis of other natural products bearing the megastigmane moiety, as well as to the enantioselective synthesis of aripuanin derivatives. |
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| Keywords: | Aripuanin Ficus aripuanensis megastigmane natural product synthesis |
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