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AlCl3/PCC-SiO2-Promoted Oxidation of Azaindoles and Indoles |
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| Authors: | Rekulapally Sriram Chebolu Naga Sesha Sai Pavan Kumar Nerella Raghunandan Vadla Ramesh |
| Institution: | 1. Organic Chemistry Division II, Indian Institute of Chemical Technology, Tarnaka , Hyderabad , India;2. University College of Pharmaceutical Sciences, Kakatiya University , Warangal , India;3. Organic Chemistry Division II, Indian Institute of Chemical Technology, Tarnaka , Hyderabad , India;4. University College of Pharmaceutical Sciences, Kakatiya University , Warangal , India |
| Abstract: | Abstract A simple and efficient method is described for the oxidation of 7-azaindoles and indoles to 7-azaisatins and isatins using pyridinium chlorochromate–silica gel (PCC-SiO2) with the aid of Lewis acid catalyst aluminium chloride (AlCl3) in dichloroethane. Simplicity of the reaction conditions, easy workup procedure, and good yields are the key features of this protocol. |
| Keywords: | Aluminium chloride (AlCl3) azaindoles azaisatins indoles isatins oxidation pyridinium chlorochromate (PCC) |