Azlactone Synthesis. 2-Phenyl-2-Oxazolin-5-One |
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| Authors: | C F Hoyng M McKenna K Novak |
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| Institution: | 1. Department of Chemistry , Texas A&2. M University College Station , Texas, 77843 |
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| Abstract: | Abstract 2-Phenyl-2-oxazolin-5-one (3) has been used as an intermediate in the synthesis of α-amino acids1, derivatives of α-amino acids,2 and peptides.3 Procedures for the dehydration/cyclization of hippuric acid (1) leading to the isolation of azlactone 3, have been reported using acetic anhydride,4 phosphorus trihalides5, and N, N′-dicyclohexylcarbodiimide.6 We report herein an alternative, high yield procedure utilizing a water soluble carbodiimide. |
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