Comparison of photodynamic efficacy of tetraarylporphyrin pegylated or encapsulated in liposomes: In vitro studies |
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| Authors: | Kinga Nawalany, Aleksandra Rusin, Mariusz K&#x pczy&#x ski, Alexei Mikhailov, Gabriela Kramer-Marek, Miros&#x aw
nietura, Jan Po&#x towicz, Zdzis&#x aw Krawczyk,Maria Nowakowska |
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| Affiliation: | aFaculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Kraków, Poland;bMaria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Wybrzeże Armii Krajowej 15, 44-100 Gliwice, Poland;cInstitute of Catalysis and Surface Chemistry, Polish Academy of Sciences, Niezapominajek 8, 30-239 Kraków, Poland |
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| Abstract: | Two photosensitizing systems: (1) tetrakis(4-hydroxyphenyl)porphyrin (p-THPP) encapsulated in sterically stabilized liposomes (SSL) and (2) p-THPP functionalized by covalent attachment of poly(ethylene glycol) (p-THPP–PEG2000) were studied in vitro. The dark and photo cytotoxicity of these systems were evaluated on two cell lines: HCT 116, a human colorectal carcinoma cell line, and DU 145, a prostate cancer cell line and compared with these determined for free p-THPP. It was demonstrated that both encapsulation in liposomes as well as attachment of PEG chain result in pronounced reduction of the dark cytotoxicity of the parent porphyrin. The liposomal formulation showed higher than p-THPP–PEG2000 photocytotoxicity towards both cell lines used in the studies. |
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| Keywords: | Photodynamic therapy Porphyrins Sterically stabilized liposomes Cancer cells |
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