The sugar conformation governs (6-4) photoproduct formation at the dinucleotide level |
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| Authors: | Desnous Céline Babu B Ravindra Moriou Céline Mayo Javier Ulises Ortiz Favre Alain Wengel Jesper Clivio Pascale |
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| Institution: | Institut de Chimie des Substances Naturelles, CNRS, 1 Avenue de la Terrasse, 91190 Gif sur Yvette, France, Nucleic Acid Center, Department of Physics and Chemistry, University of Southern Denmark, 5230 Odense M, Denmark. |
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| Abstract: | The LNA dinucleotide mimic of TpT whose two-sugar puckers are locked in the C3'-endo conformation selectively produces the corresponding cyclobutane pyrimidine dimer under 254 nm irradiation. In the natural series (TpT) the sugar puckers are in a major C2'-endo sugar conformation and the (6-4) photoproduct is also produced. Consequently, this study demonstrates that the C2'-endo conformation of the sugar pucker is necessary for (6-4) photoproduct formation. |
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