Green protocol for conjugate addition of amines to p-quinones accelerated by water |
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Authors: | Jhillu S. Yadav Basi V. Subba Reddy Tallapally Swamy Kattela Shiva Shankar |
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Affiliation: | (1) Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad, India |
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Abstract: | Amines undergo smooth conjugate addition to p-quinones in H2O at ambient temperature in the absence of a catalyst to produce 2-aminoquinones in excellent yields. Significant rate acceleration of this reaction is observed in H2O compared to organic solvents. H2O played a dual role in simultaneously activating the p-quinone and amine. This new methodology constitutes an easy, highly efficient, and green synthesis of substituted p-quinones. Correspondence: J. S. Yadav, Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, India. |
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Keywords: | Amines Conjugate addition p-Quinones 2-Aminoquinones. |
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