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| 面向穿戴或植入式临床应用的ssDNA-GFET纳米生物传感器发展现状 | |
| 引用本文： | 郝壮,刘绍琴,潘昀路.面向穿戴或植入式临床应用的ssDNA-GFET纳米生物传感器发展现状[J].科技导报(北京),2022,40(13):50-56. |
| 作者姓名： | 郝壮 刘绍琴 潘昀路 |
| 作者单位： | 1. 哈尔滨工业大学机电工程学院, 哈尔滨 150000; 2. 哈尔滨工业大学化工与化学学院, 哈尔滨 150000 |
| 基金项目： | 国家自然科学基金项目(52005137) |
| 摘 要： | 单链DNA探针-石墨烯场效应管（ssDNA-GFET）纳米生物传感器在可穿戴或可植入式临床应用领域有着广泛前景。介绍了现有ssDNA-GFET的应用、标志物检测性能提升方法、真实人体样本溶液中标志物检测，以及面向可穿戴或可植入式临床应用的柔性化研发现状，总结了ssDNA-GFET在投入实际可穿戴或可植入式临床应用前有待解决的问题。 |
| 关 键 词： | 单链 DNA探针 石墨烯 场效应管 生物传感器 柔性电子 |
| 收稿时间： | 2021-04-26 |
Development status of ssDNA-GFET nano-biosensors toward wearable or implantable clinical applications |
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| HAO Zhuang,LIU Shaoqin,PAN Yunlu.Development status of ssDNA-GFET nano-biosensors toward wearable or implantable clinical applications[J].Science & Technology Review,2022,40(13):50-56. | |
| Authors: | HAO Zhuang LIU Shaoqin PAN Yunlu |
| Institution: | 1. School of Mechatronics Engineering, Harbin Institute of Technology, Harbin 150000, China; 2. School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150000, China |
| Abstract: | Single strand DNA probe-graphene field effect transistor (ssDNA-GFET) nano-biosensor holds great potential in wearable or implantable clinic applications. This paper reviews the development status of ssDNA-GFET, methods on optimizing biomarker sensing performance, detection of biomarkers in human biofluids, and the development status of flexible ssDNA-GFET toward wearable or implantable clinic applications. In the end, the paper demonstrates current limitations of the sensor that hampers its real clinic applications. |
| Keywords: | single strand DNA probe graphene FET biosensor flexible electronics |
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