Iron hydroxide nanoparticles coated with poly(ethylene glycol)-poly(aspartic acid) block copolymer as novel magnetic resonance contrast agents for in vivo cancer imaging |
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Authors: | Michiaki Kumagai Yutaka Imai Teisaku Nakamura Yuichi Yamasaki Masaki Sekino Shoogo Ueno Kenjiro Hanaoka Kazuya Kikuchi Tetsuo Nagano Eiji Kaneko Kentaro Shimokado Kazunori Kataoka |
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Abstract: | PEG-coated β-FeOOH nanoparticles were prepared through electrostatic complex formation of iron oxide nanoparticles with poly(ethylene glycol)-poly(aspartic acid) block copolymer PEG-P(Asp)] in distilled water. By dynamic light scattering (DLS) measurement, the nanopaticle size was determined to be 70 nm with narrow distribution. The FT-IR and zeta potential experimental results proved that PEG-PAsp molecules bound to the surface of the iron oxide nanoparticles via the coordination between the carboxylic acid residues in the PAsp segment of the block copolymer and the surface Fe of the β-FeOOH nanoparticles. The PEG-coated nanoparticles revealed excellent solubility and stability in aqueous solution as well as in physiological saline. In vivo MRI experiments on tumor-bearing mice demonstrated that the PEG-coated nanoparticles prepared by the current approach achieved an appreciable accumulation into solid tumor, suggesting their potential utility as tumor-selective MRI contrast agents. |
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Keywords: | Magnetic resonance imaging Tumor Contrast agent β -FeOOH Poly(ethylene glycol) Block copolymer Zeta potential FT-IR |
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