Polymer-assisted, multi-step solution phase synthesis and biological screening of histone deacetylase inhibitors |
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| Authors: | Bapna Akanksha Vickerstaffe Emma Warrington Brian H Ladlow Mark Fan Tai-Ping D Ley Steven V |
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| Affiliation: | GlaxoSmithKline Cambridge Technology Centre, University Chemical Laboratory, Lensfield Road, Cambridge, UK. |
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| Abstract: | The polymer-assisted solution phase synthesis (PASP) of an array of histone deacetylase (HDAc) inhibitors is described. HDAc inhibitors have considerable potential as new anti-proliferative agents. Selected compounds were shown to inhibit both human endothelial cell proliferation, and the formation of tubules (neovascularisation) in an in vitro model of angiogenesis. |
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