Efficient resolution of 2,2'-dihydroxy-1,1'-binaphthyl by inclusion complexation with chiral N-(3-chloro-2-hydroxypropyl)-N,N,N-trimethylammonium chloride |
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Authors: | Toda Fumio Yoshizawa Kazuhiro Hyoda Shunji Toyota Shinji Chatziefthimiou Spyros Mavridis Irene M |
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Affiliation: | Department of Chemistry, Faculty of Science, Okayama University of Science, Okayama 700-0005, Japan. toda@chem.ous.ac.jp |
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Abstract: | The complete resolution of 2,2[prime or minute]-dihydroxy-1,1[prime or minute]-binaphthyl into its enantiomers by inclusion complexation with a commercially available derivative of choline, is reported. The two enantiomers are recovered in >99% ee from the inclusion complexes by simple dissolution in a diethyl ether-water medium and the resolving agent can be recycled. |
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