Alkylation,amino(hydroxy)methylation,and cyanoethylation of 5-substituted 4-phenyl-4<Emphasis Type="Italic">H</Emphasis>-1,2,4-triazole-3-thiols |
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Authors: | M A Kaldrikyan N S Minasyan R G Melik-Ogandzanyan |
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Abstract: | Reactions of 1,2,4-triazole-3-thiols with 2-bromopropionic acid, 2-bromocaproic acid, ethylene chlorohydrine, chloroacetamide, 3-bromo-4-methoxybenzyl chloride, 2-methoxy-5-acetylbenzyl chloride, and 2-(2-chlorophenoxy)ethyl chloride in the presence of KOH have afforded new 3-sulfanyl-1,2,4-triazoles in high yields. Aminomethylation of 1,2,4-triazole-3-thiols in the presence of formaldehyde has given the corresponding 2-aminomethyl-2H-1,2,4-triazole-3(4H)-thiones. Interaction of triazole-3-thiols with formalin and acrylonitrile has resulted in the formation of N2-hydroxymethyl- and 3-(2-cyanoethyl)sulfanyl derivatives. |
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