NMR study of 1,7-diamino-4-oxyheptane-1,1,7,7-tetraphosphonic acid interaction with samarium(III) cation |
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Authors: | G S Tsebrikova V E Baulin I P Kalashnikova V V Ragulin V O Zavel’skii G E Kodina A Yu Tsivadze |
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Abstract: | 1,7-Diamino-4-oxypentane-1,1,7,7-tetraphosphonic acid has been synthesized while searching for potential components for 153Sm radiopharmaceuticals. Its interaction with samarium(III) cation has been studied by 13C and 31P NMR spectroscopy in comparison with 1,5-diamino-3-oxypentane-N,N'-tetra-(methylenephosphonic acid) which is the ligand component of the osteotropic drug Samarium 153Sm oxabifore. NMR spectroscopy provides a simple, convenient, and informative method for studying interactions between the ligand and prospective radionuclide cation. |
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