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The effect of the chromophoric group modification on the optical properties of retinal proteins |
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| Authors: | Nikolay E Belikov Irina A Melnikova Olga V Demina Lada E Petrovskaya Elena A Kryukova Dmitriy A Dolgikh Pavel K Kuzmichev Vladimir V Chupin Alexey Yu Lukin Alexei N Shumsky Igor Chizhov Peter P Levin Mikhail P Kirpichnikov Sergei D Varfolomeev Andrey A Khodonov |
| Institution: | 1. N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, 119334 Moscow, Russian Federation;2. M. M. Shemyakin–Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russian Federation;3. Moscow Institute of Physics and Technology, 141700 Dolgoprudnyi, Moscow Region, Russian Federation;4. Institute of Fine Chemical Technologies, Moscow Technological University, 119571 Moscow, Russian Federation;5. Institute for Biophysical Chemistry, Hannover Medical School, 30625 Hannover, Germany |
| Abstract: | The effects of chromophoric group structures on the functional properties of bacteriorhodopsin (BR) and proteorhodopsin from E. sibiricum (ESRh) were compared. ESRh retinal binding site was found as preserving the similar stereo- and spatial restrictions on the chromophore structure during the retinal protein reconstitution process (except for C25-analog AR8). It was revealed that the structure peculiarities of the chromophore analog molecules affect the optical parameters of ESRh and BR pigment families in similar ways. |
| Keywords: | Corresponding author Fax: ++7 499 137 6420 |
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