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New 5-arylamino-4-(5-nitrofuran-2-yl)pyrimidines as promising antibacterial agents |
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| Authors: | Egor V Verbitskiy Svetlana A Baskakova Natal’ya A Gerasimova Natal’ya P Evstigneeva Natal’ya V Zil’berberg Nikolay V Kungurov Marionella A Kravchenko Gennady L Rusinov Oleg N Chupakhina Valery N Charushin |
| Institution: | 1. I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 620990 Ekaterinburg, Russian Federation;2. Institute of Chemical Engineering, Ural Federal University, 620002 Ekaterinburg, Russian Federation;3. Ural Research Institute for Dermatology, Venereology and Immunopathology, 620076 Ekaterinburg, Russian Federation;4. Ural Research Institute for Phthisiopulmonology, 620039 Ekaterinburg, Russian Federation |
| Abstract: | A facile synthetic approach to 5-arylamino-4-(5-nitrofuran- 2-yl)pyrimidines by the Buchwald–Hartwig cross-coupling with various anilines has been developed. All synthesized compounds demonstrated a significant level of in vitro antibacterial activity against Neisseria gonorrhoeae, Streptococcus pyogene and Staphylococcus aureus, including their drug-resistant strains, which is much higher than that of the commercial drug Spectinomycin. |
| Keywords: | Corresponding author |
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