| 3,3-二甲基-1-(1H-1,2,4-三唑-1-基)-2-丁酮及1-(1H-1,2,4-三唑-1-基)取代苯乙酮与二溴化物的关环反应及产物的生物活性 |
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| 引用本文： | 张耀谋,陈文彬,金桂玉.3,3-二甲基-1-(1H-1,2,4-三唑-1-基)-2-丁酮及1-(1H-1,2,4-三唑-1-基)取代苯乙酮与二溴化物的关环反应及产物的生物活性[J].高等学校化学学报,2003,24(3):431-435. |
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| 作者姓名： | 张耀谋 陈文彬 金桂玉 |
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| 作者单位： | 南开大学元素有机化学研究所, 元素有机化学国家重点实验室, 天津 300071 |
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| 基金项目： | 国家自然科学重点基金 (批准号 :2 9832 0 5 0 )资助 |
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| 摘 要： | 通过二溴化物与唑酮1R=(CH3)3C]或α-三唑基苯乙酮1(R=Ar)的亲核取代反应,合成了新型的环状三唑类化合物3和4,经元素分析,1HNMR,IR,EI-MS和X射线衍射等方法确证其结构,讨论了反应过程.生物活性测试发现大部分化合物具有很好的杀菌活性,尤其对小麦锈病具有较强的抑制作用.
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| 关 键 词： | 三唑 二溴化物 亲核取代反应 生物活性 |
| 文章编号： | 0251-0790(2003)03-0431-05 |
| 收稿时间： | 2002-02-26 |
Cyclization Reactions of 3,3-Dimethyl-1-(1H-1,2,4-triazolo-1-yl)-2-butanone or Substituted 1-(1H-1,2,4-Triazolo-1-yl)acetophenone with Dibromide Compounds and Its Biological Activities |
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| ZHANG Yao-Mou,CHEN Wen-Bin,JIN Gui-Yu.Cyclization Reactions of 3,3-Dimethyl-1-(1H-1,2,4-triazolo-1-yl)-2-butanone or Substituted 1-(1H-1,2,4-Triazolo-1-yl)acetophenone with Dibromide Compounds and Its Biological Activities[J].Chemical Research In Chinese Universities,2003,24(3):431-435. |
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| Authors: | ZHANG Yao-Mou CHEN Wen-Bin JIN Gui-Yu |
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| Institution: | State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China |
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| Abstract: | The title compounds 3 and 4 were prepared by nucleophilic substitution reaction of compounds 1 with dibromide 2. Their structures were determined by elementary analysis, 1H NMR, IR, EI-MS and X-ray diffraction method. The reaction procedure was also studied in detail. From the screening results of biological activities, most compounds possess good fungicidal activities, especially against Puccinia recondita. |
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| Keywords: | Triazole Dibromide Nucleophilic substitution reaction Biological activities |
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