Differential pulse polarographic determination of Co(II) using moxifloxacine |
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Authors: | R İnam H Mercan E Yılmaz B Uslu |
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Institution: | (1) Faculty of Arts and Sciences, Department of Chemistry, Gazi University, 06500 Ankara, Turkey;(2) Faculty of Pharmacy, Department of Analytical Chemistry, Ankara University, 06100 Tandogan, Ankara, Turkey |
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Abstract: | The polarographic reduction of Co(II) in the presence of moxifloxacin (1-cyclopropyl-7-(S,S)-2.8-diazabicyclo4.3.0]non-8-yl]-6-fluoro-8-methoxy-1.4-dihydro-4-oxo-3-quinolinecarboxylic
acid) gives rise to an additional adsorption peak corresponding to the reduction of Co(II)-moxifloxacin complex on the mercury
drop electrode at −1.17 V. This new peak is applicable to Co(II) determination with the linearity proportional to the Co(II)
concentration in the range of 4.93 × 10−7−6.90 × 10−5 M and can be attributed to an adsorption-controlled process with an irreversible reduction. Without using moxifloxacin, the
polarographic determination of 2.50 × 10−6 M Co(II) is impossible under the given conditions due to very poor sensitivity at −1.38 V. The proposed method showed good
precision and accuracy with a relative standard deviation of 3.01% and relative error of +6.40% for the determination of 2.50
× 10−6 M Co(II) next to 5.0 × 10−6 M of Zn(II), Ni(II), and Cd(II). The accuracy of the method was also checked by the determination of Co(II) spiked with tap
water and certified sea water, and the percentage recoveries were 97.5 and 96.7%, respectively (n = 4 at 95% confidence interval).
The text was submitted by the authors in English. |
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Keywords: | differential pulse polarography Co(II) determination moxifloxacin |
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