The reactions of some halogenated pyridines with methoxide and methanethiolate ions in dimethylformamide |
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Authors: | Lorenzo Testaferri Marcello Tiecco Marco Tingoli Donatella Bartoli Alberto Massoli |
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Affiliation: | Istituto di Chimica Organica, Facoltà di Farmacia, Università di Perugia, Italy |
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Abstract: | The reactions of 2,6- and 2,5-dibromopyridines and of 2,3- and 3,5-dichloropyridines with sodium isopropanethiolate and methanethiolate afforded the products of mono- or of bis-substitution depending on the experimental conditions. The same pyridines reacted with sodium methoxide to give good yields of the mono-substituted products; bis-substitution occurred easily only in the case of the 2,6-dibromo- and of the 3,5-dichloropyridine. The syntheses of some methoxy thiomethoxypyridine, starting from the halogeno methoxypyridines or from the halogeno thiomethoxypyhdines are also described. The bis-(alkylthio)pyridines can be fragmented by sodium in HMPA to give the bis(mercapto)pyridines. |
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