Dendritic structures based on bis(hydroxymethyl)propionic acid as platforms for surface reactions

In this paper we present results related to the self-assembly of different generations of disulfide-cored 2,2-bis(hydroxymethyl)propionic acid-based dendritic structures onto gold surfaces. These molecular architectures, ranging from generation 1 to generation 3, contain removable acetonide protecting groups at their periphery that are accessible for hydrolysis with subsequent formation of OH-terminated surface-attached dendrons. The deprotection has been investigated in detail as a versatile approach to accomplish reactive surface platforms. A special focus has been devoted to the comparison of the properties of the layers formed by hydrolysis of the acetonide moieties directly on the surface and in solution, prior to the layer formation.