| 顶空-毛细管柱气相色谱法测定盐酸艾司洛尔中有机溶剂的残留量 |
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| 引用本文： | 肖小武,李婷婷,程奇珍,熊蔚,易路遥,罗跃华. 顶空-毛细管柱气相色谱法测定盐酸艾司洛尔中有机溶剂的残留量[J]. 理化检验(化学分册), 2012, 0(7): 848-850 |
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| 作者姓名： | 肖小武 李婷婷 程奇珍 熊蔚 易路遥 罗跃华 |
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| 作者单位： | 江西省食品药品检验所;南昌大学药学院;成都市食品药品检测中心 |
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| 基金项目： | 国家十一五科技支撑计划(2008BA155B00) |
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| 摘 要： | 提出了顶空-气相色谱法测定盐酸艾司洛尔中甲醇、乙醇、丙酮、异丙醇、乙醚、吡啶和甲苯7种有机溶剂残留量的方法。选择顶空平衡温度和时间分别为70℃和30min,用DB-1 125-1032毛细管柱分离,火焰离子化检测器检测。7种芳香烃化合物在一定的质量浓度范围内与其峰面积呈线性关系,方法的检出限(3S/N)在0.5～3.8mg·L-1之间。在2个浓度水平上做回收试验,加标回收率在96.2%～102.7%之间,相对标准偏差(n=9)在0.69%～3.0%之间。
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| 关 键 词： | 顶空-毛细管柱气相色谱法 盐酸艾司洛尔 残留有机溶剂 |
Head Space-Capillary Column GC Determination of Residual Amounts of Organic Solvents in Esmolol Hydrochloride |
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| XIAO Xiao-wu,LI Ting-ting,CHENG Qi-zhen,XIONG Wei,YI Lu-yao,LUO Yue-hua. Head Space-Capillary Column GC Determination of Residual Amounts of Organic Solvents in Esmolol Hydrochloride[J]. Physical Testing and Chemical Analysis Part B:Chemical Analgsis, 2012, 0(7): 848-850 |
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| Authors: | XIAO Xiao-wu LI Ting-ting CHENG Qi-zhen XIONG Wei YI Lu-yao LUO Yue-hua |
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| Affiliation: | 1,2(1.Jiangxi Institute for Drug and Food Control,Nanchang 330029,China; 2.College of Pharmacy,Nanchang University,Nanchang 330046,China; 3.Chengdu Municipal Inspection Center for Food and Drug,Chengdu 610045,China) |
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| Abstract: | Head space-GC was applied to the determination of 7 organic solvents,including methanol,ethanol,acetone,isopropanol,diethyl ether,pyridine and methylbenzene,in esmolol hydrochloride.The balanced temperature and time of head space were set out at 70 ℃ and 30 min.The analyte were separated on DB-1 125-1032 capillary column and detected by FID.Linear relationships between values of peak area and mass concentration of 7 organic solvents were kept in definite ranges.Detection limits(3S/N) found were ranged from 0.5 to 3.8 mg·L-1.Tests for recovery were performed by addition of mixed standard of 7 organic solvents at 2 concentration levels for 9 parallel determinations,results of recovery found were in the range of 96.2%-102.7% with RSD′s in the range of 0.69%-3.0%. |
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| Keywords: | Head space-capillary column GC Esmolol hydrochloride Residual organic solvents |
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