The use of internal quality control materials for the preparation and maintenance of reliable methods for the measurement of lead in blood |
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| Authors: | Andrew Taylor |
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| Affiliation: | (1) Trace Elements Laboratory, Robens Institute of Industrial and Environmental Health and Safety, University of Surrey, GU1 5XH Guildford, Surrey, UK;(2) Department of Clinical Biochemistry and Clinical Nutrition, St Luke's Hospital, GU1 3NT Guildford, Surrey, UK |
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| Abstract: | Summary The performance of a group of reference laboratories measuring lead in blood, has been monitored by an intensive external quality assessment programme, since 1974. Performance was similar to that observed in other, larger quality control surveys but rapidly improved following detailed investigations of critical factors in the analytical methodology. The introduction of a rigorous internal quality control protocol, with all laboratories using the same well-characterised materials, has produced external quality control results that are both accurate and very tightly distributed. Between-laboratory coefficients of variation of less than 5%, less than 6% and less than 20% are now obtained at concentrations of over 1.0  mol/l (20.7 g/dl), 0.5–1.0 mol/l (10–20 g/dl) and less than 0.5 umol/l (10 g/dl), respectively. These results represent the best that can be achieved by current methodology and instrumentation in regular, daily use.
Verwendung interner Qualitätskontrollmaterialien für die Erarbeitung und Anwendung zuverlässiger Methoden zur Messung von Blei in Blut
Presented on behalf of the Trace Elements Sub-group of the Supraregional Assay Service (SAS) of the UK National Health Service |
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