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New 11-Methoxymethylgermacranolides from the Whole Plant of Carpesium divaricatum |
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| Authors: | Tao Zhang Haixin Zhang Chunyu Lin Lu Fu Zhongmei Zou |
| Affiliation: | 1.Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China;2.Key Laboratory of Quality Research in Chinese Medicine, Guangdong-Hong Kong Macao Joint Laboratory of Respiratory Infectious Disease, Macau Institute for Applied Research in Medicine and Health, College of Pharmacy, Macau University of Science and Technology, Macau 999078, China |
| Abstract: | Eight new 11-methoxymethylgermacranolides (1–8) were isolated from the ethanol extract of the whole plant of Carpesium divaricatum. The planar structures and relative configurations of the new compounds were determined by detailed spectroscopic analysis. The absolute configuration of 1 was established by electronic circular dichroism (ECD) spectrum and X-ray crystallographic analysis, and the stereochemistry of the new compounds 2–8 were determined by similar ECD data with 1. The absolute configurations of 5 and 7 were further confirmed by using quantum chemical electronic circular dichroism (ECD) calculations. Compound 4 exhibited weak cytotoxicity against MCF-7 cells. Compound 8 could potently decrease PGE2 productions in LPS-induced RAW 264.7 cells. |
| Keywords: | Carpesium divaricatum methoxymethylgermacranolides absolute configuration cytotoxicity PGE2 |