Bisquaternary-drug membrane electrodes with high sensitivity |
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Authors: | Vasile V Coşofreţ Richard P Buck |
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Institution: | Department of Chemistry, University of North Carolina, Chapel Hill, NC 27514 U.S.A. |
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Abstract: | The construction and performance characteristics of ion-selective plastic membrane electrodes for succinylcholine, hexamethonium and decamethonium are described. The electrodes, based on ion-pair complexes with triphenylstillbenyl borate (TPSB), show near-Nernatian responses over the range 10?2–10?6 M or less, with very low limits of detection at around 10?7 M. The responses are not affected by pH in the range 2–10. The selectivity relative to some inorganic ions, amino acids, neurotransmitters, drugs and various drug excipients is reported. |
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