Determination of mitomycin C in human blood plasma and urine by high-performance differential pulse polarography |
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| Authors: | WP van Bennekom UR Tjaden EA de Bruijn AT van Oosterom |
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| Institution: | Department of Pharmaceutical Analysis and Analytical Chemistry, Subfaculty of Pharmacy of the University of Leiden, Gorlaeus Laboratories, P.O. Box 9502, 2300 RA Leiden The Netherlands;Leiden University Medical Center, Department of Pharmacology, Leiden The Netherlands;Leiden University Medical Center, Department of Clinical Oncology, Leiden The Netherlands |
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| Abstract: | High-performance differential pulse polarography is used for determining the antitumor antibiotic mitomycin C in human blood plasma and urine. The limit of determination (2-ml samples) is 25 ng ml?1 when the substance is isolated by means of Amberlite XAD-2, and 200 ng mo?1 when samples are not pretreated. The method was applied in a pharmacokinetic experiment; no metabolites of mitomycin C were observed in urine or plasma. |
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