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Synthesis of tetrahydroisoquinoline derivatives and evaluation of their anti-breast cancer activity |
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| Authors: | X P Zhang F J Yu X W Ding X M He D H Zou |
| Abstract: | Four novel tetrahydroisoquinoline derivatives 1–4 were synthesized and characterized by IR, 1H NMR, HRMS, and single crystal X-ray crystallography. Anticancer effect of the products were studied on five human breast cancer cell lines including MDA-MB-231, MDA-MB-468, SK-BR-3, MCF7, HCC70 T4-2. Compounds 3 and 4 demonstrated higher activity than 1 and 2. |
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