Synthesis of putative chain terminators of mycobacterial arabinan biosynthesis |
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Authors: | Smellie Iain A Bhakta Sanjib Sim Edith Fairbanks Antony J |
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Institution: | Chemistry Research Laboratory, Oxford University, Mansfield Road, Oxford, UK OX1 3TA. |
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Abstract: | The synthesis of a variety of arabinose derivatives that have been modified at C-5 was achieved from d-arabinose. The 5-fluoro and 5-methoxy compounds were converted into the corresponding farnesyl phosphodiesters as putative chain terminators of mycobacterial arabinan biosynthesis. Biological testing of these materials revealed no effective anti-mycobacterial activity. |
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