2-methylpyridinium 5-(2,4-dinitrophenyl)-6-oxo-2-thioxo-1,2,3,6-tetrahydropyrimidin-4-olate: Synthesis,crystal structure,and biological evaluation |
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Authors: | G. Mangaiyarkarasi G. Sridevi P. Poornima Devi D. Kalaivani |
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Affiliation: | 1.PG and Research Department of Chemistry,Seethalakshmi Ramaswami College,Tamil Nadu,India |
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Abstract: | The titled complex is synthesized from the ethanolic solutions of 1-chloro-2,4-dinitrobenzene, 2-thiobarbituric acid, and 2-methylpyridine and characterized by spectral and elemental analyses. The single crystal X-ray diffraction results for the complex are compatible with the spectral observations. The titled complex exhibits anticonvulsant activity and reduces all phases of convulsion even at a low dosage. Acute toxicity studies of the complex are performed to understand the safer dose concentration for clinical trials. |
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