Voltammetric study of nifuroxazide at unmodified and Sephadex-modified carbon paste electrodes |
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Authors: | A Radi |
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Institution: | (1) Chemistry Department, Faculty of Science, Mansoura University, 34517 Demiatta, Egypt, EG |
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Abstract: | The electrooxidation of nifuroxazide was investigated by cyclic and differential-pulse voltammetry at carbon paste and Sephadex-modified
carbon paste electrodes. Nifuroxazide is irreversibly oxidized at all pH values and gives rise to a well-defined oxidation
peak. The modification of the carbon paste surface with Sephadex allowed a preconcentration process to take place for nifuroxazide
such that higher sensitivity was achieved compared with the bare surface. The influence of the scan rate, time of accumulation,
modifier loading, solution conditions and pH on the adsorptive step at the modified carbon paste electrodes was investigated.
The direct determination of the drug in urine is also discussed.
Received: 2 June 1998 / Revised: 29 January 1999 / Accepted: 2 February 1999 |
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