Altered maternal profiles in corticotropin-releasing factor receptor 1 deficient mice |
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| Authors: | Stephen C Gammie Emily D Bethea Sharon A Stevenson |
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| Institution: | (1) Department of Zoology, University of Wisconsin, 53706 Madison, Wisconsin, USA;(2) Neuroscience Training Program, University of Wisconsin, 53706 Madison, Wisconsin, USA |
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| Abstract: | Background During lactation, the CNS is less responsive to the anxiogenic neuropeptide, corticotropin-releasing factor (CRF). Further,
central injections of CRF inhibit maternal aggression and some maternal behaviors, suggesting decreased CRF neurotransmission
during lactation supports maternal behaviors. In this study, we examined the maternal profile of mice missing the CRF receptor
1 (CRFR1). Offspring of knockout (CRFR1-/-) mice were heterozygote to offset possible deleterious effects of low maternal
glucocorticoids on pup survival and all mice contained a mixed 50:50 inbred/outbred background to improve overall maternal
profiles and fecundity. |
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