| 3-CH_2CH_2COOCH_3取代的1,5-苯并硫氮杂衍生物的合成、晶体结构及抑菌活性研究 |
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| 引用本文： | 张萍,宣烨,刘薇,李媛.3-CH_2CH_2COOCH_3取代的1,5-苯并硫氮杂衍生物的合成、晶体结构及抑菌活性研究[J].有机化学,2011,31(8). |
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| 作者姓名： | 张萍 宣烨 刘薇 李媛 |
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| 作者单位： | 1. 河北师范大学化学与材料科学学院 石家庄050016
2. 河北师范大学生命科学学院 石家庄050016 |
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| 基金项目： | 国家自然科学基金(No.20972040); 河北省自然科学基金(No.B2009000255)资助项目 |
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| 摘 要： | 从不同取代的苯出发,经5步反应合成了一系列3-CH2CH2COOCH3取代的1,5-苯并硫氮杂衍生物.化合物的结构经IR,1H NMR,13C NMR,MS和元素分析确证,并用X射线单晶衍射测定了化合物5f的晶体结构,证实了分子中的七元杂环是类船式构象.初步的抑菌活性测试结果表明,化合物5f和5h对枯草芽孢杆菌和临床新生隐球菌有微弱的抑制作用.
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| 关 键 词： | 1 5-苯并硫氮杂 晶体结构 抑菌活性 |
Synthesis,Crystal Structure and Antibacterical Properties of 3-CH_2CH_2COOCH_3 Substituted 1,5-Benzothiazepines |
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| Zhang Ping,Xuan Ye,Liu Wei,Li Yuan.Synthesis,Crystal Structure and Antibacterical Properties of 3-CH_2CH_2COOCH_3 Substituted 1,5-Benzothiazepines[J].Chinese Journal of Organic Chemistry,2011,31(8). |
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| Authors: | Zhang Ping Xuan Ye Liu Wei Li Yuan |
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| Institution: | Zhang,Pinga Xuan,Yea Liu,Weib Li,Yuan*,a(a College of Chemistry,Hebei Normal University,Shijiazhuang 050016)(b College of Life Science,Shijiazhuang 050017) |
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| Abstract: | Starting from substituted benzenes,a series of 3-CH2CH2COOCH3 substituted 1,5-benzothi-azepines were synthesized through 5-step reactions.The structures of the new products were confirmed by IR,1H NMR,13C NMR,MS techniques and elemental analysis.The crystal structure of the compound 5f has been deterimined by X-ray diffraction analysis and the conformation of the seven-membered heterocycle is boat-like.The preliminary antibacterical experimental results showed that 5f and 5h have weak activities to Bacillus... |
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| Keywords: | 1 5-benzothiazepine crystal structure antibacterical propertiy |
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